New publication: looking at how sensory nerves direct skin cell function
Although we know that having innervation in the skin is important for successful wound healing, relatively little is known about what resident nerves do after injury. The lab published new work using an in vitro model to determine how sensory nerves can direct keratinocyte functions that are important for skin maintenance and wound healing. We both characterized the nerve secretome, and found that culture of keratinocytes in sensory-nerve conditioned media changes cell migration, proliferation, fate, and metabolic activity. These findings have important implications for understanding how skin wound healing occurs and may point the way towards neural-based therapeutics to improve healing in dysregulated states.
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